16th Wildland Shrub Symposium Threats to Shrubland Ecosystem Integrity 2010 May 18-20 Logan, UT

Abstract: The 29 papers in this proceedings are divided into the main organized sessions of the 16th Wildland Shrub Symposium, including the plenary session to introduce the theme of threats to shrubland ecosystem integrity, impacts of energy development and reclamation on ecosystem function, invasive plant ecology. wildlife habitats: impacts and restoration opportunities, historical perspectives in shrublands, ecosystem threats due to fire in the Mojave Desert, and modeling and monitoring of shrubland ecosystems. An overarching goal of the symposium was to make linkages between research and management

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers